suPAR is a biomarker and
therapeutic target for AKI

More Details

More Details

Catalytic iron is a biomarker

and therapeutic target in AKI

More Details

A common genetic variant in HO-1 predicts risk of AKI following cardiac surgery

More Details

Immune checkpoint inhibitors cause AKI through tubulo-interstitial nephritis

More Details

FGF23 is an early marker of AKI
and death after cardiac surgery
and in critically ill patients


An overview of our projects


A portfolio with a list of our publications


Get to know more about the PI


Get to know more about our team

The Leaf Lab conducts patient-oriented research in acute kidney injury (AKI) and critical illness. Our goal is to develop novel approaches to prevent AKI, and to improve outcomes in patients who suffer from AKI. Read more about AKI.

Our research is highly collaborative and interdisciplinary and includes:

•  Randomized trials
•  Biomarker studies
•  Genetics
•  Epidemiology


APEX Pilot Grant

May 2024
Rebecca Karp Leaf was awarded a pilot grant from the American Porphyrias Expert Collaborative (APEX) for her proposal, “Evaluation of the risks and benefits of sex hormones in women with acute hepatic porphyria.”

Young Physician-Scientist Award

January, 2024
Shruti Gupta is a recipient of a Young Physician-Scientist Award from the American Society of Clinical Investigation.

JASN Associate Editor

October 9, 2023
David Leaf was selected to be an Associate Editor for the Journal of the American Society of Nephrology. His six-year term will begin in January, 2024.

Research Grant

October 1, 2023
Shruti Gupta received a Wong Family Award in Translational Oncology from Dana-Farber Cancer Institute for her proposal to study biomarkers of immune checkpoint inhibitor-associated AKI.

Grand Rounds

September 6, 2023
David Leaf presented Medicine Grand Rounds on STOP-COVID at Rush University Medical Center.

Grand Rounds

June 29, 2023
David Leaf presented Anesthesia Grand Rounds on STOP-COVID at Massachusetts General Hospital.

Grand Rounds

January 20, 2023
David Leaf gave Renal Grand Rounds on STOP-COVID at Johns Hopkins University.

Top Poster Award

September 30, 2022
Helena Kim’s poster entitled, “AKI-KRT in Allogeneic-HSCT Patients Admitted to the ICU: Incidence, Risk Factors, and Outcomes” was selected for a Top Poster Award at the American Society of Onconephrology’s annual Symposium.

Best Paper Award

September 2022
Shruti Gupta’s paper entitled, “Acute kidney injury in patients treated with immune checkpoint inhibitors” was selected by the Editorial Board of J Immunother Cancer as the best Clinical/Translational Cancer Immunotherapy Paper of 2021.

NIH R01 Grant

July 2022
David Leaf was awarded an R01 grant from the NIH/NIDDK for his proposal, “Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury.”


June 2022
David Leaf was promoted to Associate Professor of Medicine at Harvard Medical School.

Medical School Acceptance

May 2022
Congratulations to Charlotte Thomas on being accepted into Harvard Medical School!

NIH K23 Grant

January, 2022
Shruti Gupta was awarded a K23 Career Development Award from the NIH/NIDDK for her proposal, “Novel Pathways and Therapeutic Targets for Cisplatin-Associated Acute Kidney Injury.”

American Society of Onconephrology

December, 2021
Shruti Gupta is the Founder and first President of the American Society of Onconephrology!

Match Day

December 1, 2021
Congratulations to Robert Hayden for matching at the BWH/MGH Joint Nephrology Fellowship Program.

Oral Abstract and Publication

November 4, 2021
Shruti Gupta’s abstract entitled, “Acute Kidney Injury in Patients Treated with Immune Checkpoint Inhibitors” was presented as an oral abstract at ASN Kidney Week, and was published in J Immunother Cancer.

Top Paper Award

January 27, 2021
Shruti Gupta’s paper entitled, “AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19” was selected as one of the top 5 original research papers published in J Am Soc Nephrol in 2020.

NIH R01 Grant

September 1, 2020
David Leaf was awarded an R01 grant from the NIH/NIDDK for his proposal entitled, “Deferoxamine for the Prevention of Acute Kidney Injury.” The grant is funding DEFEAT-AKI, a phase II, multicenter, randomized, double-blind, placebo-controlled trial of iron chelation with deferoxamine for prevention of cardiac surgery-associated AKI.

NIH R01 Grant

May 1, 2019
David Leaf was awarded an R01 grant from the NIH/NHLBI for his proposal entitled, “Precision Medicine Approach to Vitamin D3 Administration in Critically Ill Patients.”