suPAR is a biomarker and
therapeutic target for AKI

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Catalytic iron is a biomarker

and therapeutic target in AKI

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A common genetic variant in HO-1 predicts risk of AKI following cardiac surgery

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Immune checkpoint inhibitors cause AKI through tubulo-interstitial nephritis

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FGF23 is an early marker of AKI
and death after cardiac surgery
and in critically ill patients

Research

An overview of our projects

Publications

A portfolio with a list of our publications

Bio

Get to know more about the PI

Team

Get to know more about our team

The Leaf Lab conducts patient-oriented research in acute kidney injury (AKI) and critical illness. Our goal is to develop novel approaches to prevent AKI, and to improve outcomes in patients who suffer from AKI. Read more about AKI.

Our research is highly collaborative and interdisciplinary and includes:

•  Randomized trials
•  Biomarker studies
•  Genetics
•  Epidemiology

News

NIH U01 Grant

September, 2024
David Leaf, Shalender Bhasin, and Stephen Gardell were awarded a $5.7 million U01 grant from the NIH/NIA for their proposal, “Development, Validation, and Harmonization of Methods for Collection and Measurement of NAD+ and Related Metabolites: Application to a Randomized Trial of Patients Undergoing Coronary Artery Bypass.”

Publication

August, 2024
Shruti Gupta and David Leaf’s paper, “F18-FDG PET imaging as a diagnostic tool for immune checkpoint inhibitor-associated acute kidney injury“, was published in JCI.

APEX Pilot Grant

May 2024
Rebecca Karp Leaf was awarded a pilot grant from the American Porphyrias Expert Collaborative (APEX) for her proposal, “Evaluation of the risks and benefits of sex hormones in women with acute hepatic porphyria.”

Young Physician-Scientist Award

January, 2024
Shruti Gupta is a recipient of a Young Physician-Scientist Award from the American Society of Clinical Investigation.

JASN Associate Editor

October 9, 2023
David Leaf was selected to be an Associate Editor for the Journal of the American Society of Nephrology. His six-year term began in January, 2024.

Research Grant

October 1, 2023
Shruti Gupta received a Wong Family Award in Translational Oncology from Dana-Farber Cancer Institute for her proposal to study biomarkers of immune checkpoint inhibitor-associated AKI.

Best Paper Award

September 2022
Shruti Gupta’s paper entitled, “Acute kidney injury in patients treated with immune checkpoint inhibitors” was selected by the Editorial Board of J Immunother Cancer as the best Clinical/Translational Cancer Immunotherapy Paper of 2021.

NIH R01 Grant

July 2022
David Leaf was awarded an R01 grant from the NIH/NIDDK for his proposal, “Hepcidin-Ferroportin-Iron Axis in Cardiac Surgery-associated Acute Kidney Injury.”

Medical School Acceptance

May 2022
Congratulations to Charlotte Thomas on being accepted into Harvard Medical School!

NIH K23 Grant

January, 2022
Shruti Gupta was awarded a K23 Career Development Award from the NIH/NIDDK for her proposal, “Novel Pathways and Therapeutic Targets for Cisplatin-Associated Acute Kidney Injury.”

American Society of Onconephrology

December, 2021
Shruti Gupta is the Founder and first President of the American Society of Onconephrology!

Top Paper Award

January 27, 2021
Shruti Gupta’s paper entitled, “AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19” was selected as one of the top 5 original research papers published in J Am Soc Nephrol in 2020.

NIH R01 Grant

September 1, 2020
David Leaf was awarded an R01 grant from the NIH/NIDDK for his proposal entitled, “Deferoxamine for the Prevention of Acute Kidney Injury.” The grant is funding DEFEAT-AKI, a phase II, multicenter, randomized, double-blind, placebo-controlled trial of iron chelation with deferoxamine for prevention of cardiac surgery-associated AKI.

NIH R01 Grant

May 1, 2019
David Leaf was awarded an R01 grant from the NIH/NHLBI for his proposal entitled, “Precision Medicine Approach to Vitamin D3 Administration in Critically Ill Patients.”