Publications

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2021

Leaf DE, Hayek SS. Questioning the Futility of Cardiopulmonary Resuscitation in Patients With Severe Coronavirus Disease 2019. Crit Care Med. 2021 Aug 1;49(8):e795-e796. Pubmed

Mathews KS, Soh H, Shaefi S, Wang W, Bose S, Coca S, Gupta S, Hayek SS, Srivastava A, Brenner SK, Radbel J, Green A, Sutherland A, Leonberg-Yoo A, Shehata A, Schenck EJ, Short SAP, Hernán MA, Chan L, Leaf DE; STOP-COVID Investigators. Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure. Crit Care Med. 2021 Jul 1;49(7):1026-1037. Pubmed

Murakami N, Mulvaney P, Danesh M, Abudayyeh A, Diab A, Abdel-Wahab N, Abdelrahim M, Khairallah P, Shirazian S, Kukla A, Owoyemi IO, Alhamad T, Husami S, Menon M, Santeusanio A, Blosser C, Zuniga SC, Soler MJ, Moreso F, Mithani Z, Ortiz-Melo D, Jaimes EA, Gutgarts V, Lum E, Danovitch GM, Cardarelli F, Drews RE, Bassil C, Swank JL, Westphal S, Mannon RB, Shirai K, Kitchlu A, Ong S, Machado SM, Mothi SS, Ott PA, Rahma O, Hodi FS, Sise ME, Gupta S, Leaf DE, Devoe CE, Wanchoo R, Nair VV, Schmults CD, Hanna GJ, Sprangers B, Riella LV, Jhaveri KD; Immune Checkpoint Inhibitors in Solid Organ Transplant Consortium. A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant. Kidney Int. 2021 Jul;100(1):196-205. Pubmed

Chute DF, Zhao S, Strohbehn IA, Rusibamayila N, Seethapathy H, Lee M, Zubiri L, Gupta S, Leaf DE, Rahma O, Drobni ZD, Neilan TG, Reynolds KL, Sise ME. Incidence and Predictors of CKD and Estimated GFR Decline in Patients Receiving Immune Checkpoint Inhibitors. Am J Kidney Dis. 2021 Jun 23;S0272-6386(21):693-694. doi: 10.1053/j.ajkd.2021.05.012. [Epub ahead of print]. Pubmed

Friedman AN, Guirguis J, Kapoor R, Gupta S, Leaf DE, Timsina LR; STOP-COVID Investigators. Obesity, Inflammatory and Thrombotic Markers, and Major Clinical Outcomes in Critically Ill Patients with COVID-19 in the US. Obesity (Silver Spring). 2021 Jun 9. doi: 10.1002/oby.23245. [Epub ahead of print]. Pubmed

Lim ZJ, Ponnapa Reddy M, Curtis JR, Afroz A, Billah B, Sheth V, Hayek SS, Leaf DE, Miles JA, Shah P, Yuriditsky E, Jones D, Shekar K, Subramaniam A. A Systematic Review of the Incidence and Outcomes of In-Hospital Cardiac Arrests in Patients With Coronavirus Disease 2019. Crit Care Med. 2021 Jun 1;49(6):901-911. Pubmed

Babitt JL, Eisenga MF, Haase VH, Kshirsagar AV, Levin A, Locatelli F, Małyszko J, Swinkels DW, Tarng DC, Cheung M, Jadoul M, Winkelmayer WC, Drüeke TB; Conference Participants. Controversies in optimal anemia management: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Conference. Kidney Int. 2021 Jun;99(6):1280-1295. Pubmed

Lee MD, Strohbehn IA, Seethapathy HS, Rusibamayila N, Casey KS, Gupta S, Leaf DE, Frigault MJ, Sise ME. Acute Kidney Injury After the CAR-T Therapy Tisagenlecleucel. Am J Kidney Dis. 2021 Jun;77(6):990-992. Pubmed

Vasquez CR, Gupta S, Miano TA, Roche M, Hsu J, Yang W, Holena DN, Reilly JP, Schrauben SJ, Leaf DE, Shashaty MGS; STOP-COVID Investigators. Identification of Distinct Clinical Subphenotypes in Critically Ill Patients With COVID-19. Chest. 2021 May 6:S0012-3692(21)874-876. doi: 10.1016/j.chest.2021.04.062. [Epub ahead of print]. Pubmed

Gupta S, Leaf DE. Tocilizumab in COVID-19: some clarity amid controversy. Lancet. 2021 May 1;397(10285):1599-1601. Pubmed

Short SAP, Gupta S, Brenner SK, Hayek SS, Srivastava A, Shaefi S, Singh H, Wu B, Bagchi A, Al-Samkari H, Dy R, Wilkinson K, Zakai NA, Leaf DE; STOP-COVID Investigators. d-dimer and Death in Critically Ill Patients With Coronavirus Disease 2019. Crit Care Med. 2021 May 1;49(5):e500-e511. Pubmed

Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE. Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19. Ann Intern Med. 2021 May;174(5):622-632. Pubmed

Churpek MM, Gupta S, Spicer AB, Parker WF, Fahrenbach J, Brenner SK, Leaf DE; STOP-COVID Investigators. Hospital-Level Variation in Death for Critically Ill Patients with COVID-19. Am J Respir Crit Care Med. 2021 Apr 23. doi: 10.1164/rccm.202012-4547OC. [Epub ahead of print]. Pubmed

Douin DJ, Shaefi S, Brenner SK, Gupta S, Park I, Wright FL, Mathews KS, Chan L, Al-Samkari H, Orfanos S, Radbel J, Leaf DE. Tissue Plasminogen Activator in Critically Ill Adults with COVID-19. Ann Am Thorac Soc. 2021 Apr 19. doi: 10.1513/AnnalsATS.202102-127RL. [Epub ahead of print]. Pubmed

Gupta S, Leaf DE. Diphenhydramine for the prevention of cisplatin-associated acute kidney injury. Kidney Int. 2021 Apr;99(4):1025-1026. Pubmed

Molnar MZ, Kovesdy CP, Gupta S, Leaf DE. Response to “Is the outcome of SARS-CoV-2 infection in solid organ transplant recipients really similar to that of the general population?”. Am J Transplant. 2021 Apr;21(4):1672-1673. Pubmed

Hod T, Freedberg KJ, Motwani SS, Chen M, Frendl G, Leaf DE, Gupta S, Mothi SS, Richards WG, Bueno R, Waikar SS. Acute kidney injury after cytoreductive surgery and hyperthermic intraoperative cisplatin chemotherapy for malignant pleural mesothelioma. J Thorac Cardiovasc Surg 2021 Apr;161(4):1510-1518. Pubmed

Leaf DE, Ginde AA. Vitamin D3 to Treat COVID-19: Different Disease, Same Answer. JAMA. 2021 Mar 16;325(11):1047-1048. Pubmed

Li P, Gupta S, Mothi SS, Rennke HG, Leaf DE, Waikar SS, McMahon GM. Histopathologic Correlates of Kidney Function: Insights From Nephrectomy Specimens. Am J Kidney Dis. 2021 Mar;77(3):336-345. Pubmed

Shaefi S, Brenner SK, Gupta S, O’Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE; STOP-COVID Investigators. Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19. Intensive Care Med. 2021 Feb 2:1-14. Pubmed

Shaefi S, Shankar P, Mueller AL, O’Gara BP, Spear K, Khabbaz KR, Bagchi A, Chu LM, Banner-Goodspeed V, Leaf DE, Talmor DS, Marcantonio ER, Subramaniam B. Intraoperative Oxygen Concentration and Neurocognition after Cardiac Surgery. Anesthesiology. 2021 Feb 1;134(2):189-201. Pubmed

Flythe JE, Assimon MM, Tugman MJ, Chang EH, Gupta S, Shah J, Sosa MA, Renaghan AD, Melamed ML, Wilson FP, Neyra JA, Rashidi A, Boyle SM, Anand S, Christov M, Thomas LF, Edmonston D, Leaf DE; STOP-COVID Investigators. Characteristics and Outcomes of Individuals With Pre-existing Kidney Disease and COVID-19 Admitted to Intensive Care Units in the United States. Am J Kidney Dis. 2021 Feb;77(2):190-203.e1. Pubmed

Leaf DE, Gupta S, Wang W. Tocilizumab in Covid-19. N Engl J Med. 2021 Jan 7;384(1):86-87. Pubmed

Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE; and the STOP-COVID Investigators. AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19. J Am Soc Nephrol. 2021 Jan;32(1):161-176. Pubmed

Easter SR, Gupta S, Brenner SK, Leaf DE. Outcomes of Critically Ill Pregnant Women with COVID-19 in the United States. Am J Respir Crit Care Med. 2021 Jan 1;203(1):122-125. Pubmed

Hundemer GL, Srivastava A, Jacob KA, Krishnasamudram N, Ahmed S, Boerger E, Sharma S, Pokharel KK, Hirji SA, Pelletier M, Safa K, Kulvichit W, Kellum JA, Riella LV, Leaf DE. Acute kidney injury in renal transplant recipients undergoing cardiac surgery. Nephrol Dial Transplant. 2021 Jan 1;36(1):185-196. Pubmed

Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE; STOP-COVID Investigators. Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19. JAMA Intern Med. 2021 Jan 1;181(1):41-51. Pubmed

2020

Gupta S, Hayek SS, Wang W, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Sutherland A, Green A, Shehata AM, Goyal N, Vijayan A, Velez JCQ, Shaefi S, Parikh CR, Arunthamakun J, Athavale AM, Friedman AN, Short SAP, Kibbelaar ZA, Abu Omar S, Admon AJ, Donnelly JP, Gershengorn HB, Hernán MA, Semler MW, Leaf DE; STOP-COVID Investigators. Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US. JAMA Intern Med 2020 Nov 1;180(11):1-12. Pubmed

Molnar MZ, Bhalla A, Azhar A, Tsujita M, Talwar M, Balaraman V, Sodhi A, Kadaria D, Eason JD, Hayek SS, Coca SG, Shaefi S, Neyra JA, Gupta S, Leaf DE, Kovesdy CP; STOP-COVID Investigators. Outcomes of critically ill solid organ transplant patients with COVID-19 in the United States. Am J Transplant. 2020 Nov;20(11):3061-3071. Pubmed

Diwan EA, Patel AB, Cuenca AG, Elias N, Gilligan HM, Heher E, Leaf DE, Wojciechowski D, Safa K. Short Bowel Syndrome and Kidney Transplantation: Challenges, Outcomes, and the Use of Teduglutide. Case Rep Transplant. 2020 Oct 5;2020:8819345. Pubmed

Hayek SS, Brenner SK, Azam TU, Shadid HR, Anderson E, Berlin H, Pan M, Meloche C, Feroz R, O’Hayer P, Kaakati R, Bitar A, Padalia K, Perry D, Blakely P, Gupta S, Shaefi S, Srivastava A, Charytan DM, Bansal A, Mallappallil M, Melamed ML, Shehata AM, Sunderram J, Mathews KS, Sutherland AK, Nallamothu BK, Leaf DE; STOP-COVID Investigators. In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study. BMJ. 2020 Sep 30;371:m3513. Pubmed

Averdunk L, Bernhagen J, Fehnle K, Surowy H, Lüdecke HJ, Mucha S, Meybohm P, Wieczorek D, Leng L, Marx G, Leaf DE, Zarbock A, Zacharowski K, On Behalf Of The RIPHeart Study Collaborators, Bucala R, Stoppe C. The Macrophage Migration Inhibitory Factor (MIF) Promoter Polymorphisms (rs3063368, rs755622) Predict Acute Kidney Injury and Death after Cardiac Surgery. J Clin Med. 2020 Sep 11;9(9):2936. Pubmed

Leaf RK, Al-Samkari H, Brenner SK, Gupta S, Leaf DE. ABO Phenotype and Death in Critically Ill Patients with COVID-19. Br J Haematol 2020 Aug;190(4):e204-e208. Pubmed

Al-Samkari H, Karp Leaf RS, Dzik WH, Carlson JCT, Fogerty AE, Waheed A, Goodarzi K, Bendapudi PK, Bornikova L, Gupta S, Leaf DE, Kuter DJ, Rosovsky RP. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood 2020 Jul 23;136(4):489-500. Pubmed

Seethapathy H, Zhao S, Strohbehn IA, Lee M, Chute DF, Bates H, Molina GE, Zubiri L, Gupta S, Motwani S, Leaf DE, Sullivan RJ, Rahma O, Blumenthal KG, Villani AC, Reynolds KL, Sise ME. Incidence and Clinical Features of Immune-Related Acute Kidney Injury in Patients Receiving Programmed Cell Death Ligand-1 Inhibitors. Kidney Int Rep. 2020 Jul 21;5(10):1700-1705. Pubmed

Gupta S, Seethapathy H, Strohbehn IA, Frigault MJ, O’Donnell EK, Jacobson CA, Motwani SS, Parikh SM, Curhan GC, Reynolds KL, Leaf DE, Sise ME. Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma. Am J Kid Dis 2020 Jul;76(1):63-71. Pubmed

Eisenga MF, De Jong MA, Leaf DE, Nolte IM, De Borst MH, Bakker SJL, Gaillard CAJM. Erythropoietin, Fibroblast Growth Factor 23, and Death After Kidney Transplantation. J Clin Med 2020 Jun 4;9(6):1737. Pubmed

Kim EY, Ner-Gaon H, Varon J, Cullen AM, Guo J, Choi J, Barragan-Bradford D, Higuera A, Pinilla-Vera M, Short SA, Arciniegas-Rubio A, Tamura T, Leaf DE, Baron RM, Shay T, Brenner MB. Post-sepsis immunosuppression depends on NKT cell regulation of mTOR/IFN-γ in NK cells. J Clin Invest 2020 Jun 1;130(6):3238-3252. Pubmed

Hayek SS, Leaf DE, Reiser J. Soluble Urokinase Receptor and Acute Kidney Injury. Reply. N Engl J Med 2020 May 28;382(22):2167-2168. Pubmed

Seethapathy H,* Sharma S,* Zhao S, Chung RT, Connor MJ Jr, Leaf DE,† Allegretti AS.† [*Equal Contribution; †Equal Contribution] Acute Kidney Injury Following Paracentesis Among Inpatients With Cirrhosis. Kidney Int Rep 2020 May 20;5(8):1305-1308. Pubmed

Gutowski ED, Tio MC, Burch EA, Leaf DE. Peritoneal dialysate tamponading a massive retroperitoneal hemorrhage. Kidney Int 2020;97(4):810. Pubmed

Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP. Glycerol-3-phosphate is an FGF23 regulator from the injured kidney. J Clin Invest 2020;130(3):1513-1526. Pubmed

Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol 2020;31(2):435-446. Pubmed

Hayek SS,* Leaf DE,* Tahhan AS,* Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS, Holliday M, Januzzi JL, Weisboard SD, Quyyumi AA, Reiser J. [*Equal Contribution] Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med 2020;382(5):416-426. Pubmed

Gupta S, Cortazar FB, Riella LV, Leaf DE. Immune checkpoint inhibitor nephrotoxicity: Update 2020. Kidney360 2020;1(2):130-140. Link

Holliday AM, Gheihman G, Cooper C, Sullivan A, Ohyama H, Leaf DE,* Leaf RK.* [*Equal contribution]. High Prevalence of Imposterism Among Female Harvard Medical and Dental Students. J Gen Intern Med 2020;35(8):2499-2501. Pubmed

 

2019

Averdunk L, Fitzner C, Levkovich T, Leaf DE, Sobotta M, Vieten J, Ochi A, Moeckel G, Marx G, Stoppe C. Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study. J Clin Med. 2019;8(11). Pubmed

Jacob KA, Leaf DE. Prevention of Cardiac Surgery-Associated Acute Kidney Injury: A Review of Current Strategies. Anesthesiol Clin 2019;37(4):729-749. Pubmed

Seethapthy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME. The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol 2019;14(12):1692-1700. Pubmed

Sharma S, Leaf DE. Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention. J Am Soc Nephrol;30(11):2060-2071. Pubmed

Blair RA, Leaf RK, Leaf DE. A Case of Severe Hypothyroidism due to Lenalidomide. Clin Case Rep 2019;7(9):1747-1749. Pubmed

Leaf DE, Waikar SS. IDEAL-ICU in Context. Clin J Am Soc Nephrol 2019;14(8):1264-67. Pubmed

Eisenga MF, de Jong MA, der Meer PV, Leaf DE, Huls G, Nolte IM, Gaillard CAJM, Bakker SJL, de Borst MH. Iron Deficiency, Elevated Erythropoietin, Fibroblast Growth Factor 23 and Mortality in the General Population of the Netherlands: a Cohort Study. PLoS Med 2019;16(6):e1002818. Pubmed

Leaf RK, Ferreri C, Rangachari D, Mier J, Witteles W, Ansstas G, Anagnostou T, Zubiri L, Piotrowska Z, Oo TH, Iberri D, Yarchoan M, Salama A, Johnson DB, Leavitt AD, Rahma O, Reynolds KL, Leaf DE. Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors. Am J Hematol 2019;94(5):563-574. Pubmed

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS. Iron, Hepcidin, and Death in Human Acute Kidney Injury. J Am Soc Nephrol 2019;30(3):493-504. Pubmed

Srivastava A, Palsson R, Leaf DE, Higuera A, Chen ME, Palacios P, Baron RM, Sabbisetti V, Hoofnagle AN, Vaingankar SM, Palevsky PM, Waikar SS. Uric Acid and Acute Kidney Injury in the Critically Ill. Kidney Med 2019;1(1):21-30. Pubmed

Christov M, Neyra JA, Gupta S, Leaf DE. Fibroblast Growth Factor 23 and Klotho in AKI. Semin Nephrol 2019;39(1):57-75. Pubmed

Leaf DE, Christov M. Dysregulated Mineral Metabolism in AKI. Semin Nephrol 2019;39(1):41-56. Pubmed

Leaf DE. Introduction: Cross-Talk Between the Kidneys and Remote Organ Systems in AKI. Semin Nephrol 2019;39(1):1-2. Pubmed

2018

Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher AV, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med 2018;24(9):1351-59. Pubmed

Neyra JA, Leaf DE. Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu. Nephron 2018;140(2):99-104. Pubmed

Postalcioglu M, Kim HT, Obut F, Yilmam OA, Yang J, Byun BC, Kupiec-Weglinski S, Soiffer R, Ritz J, Antin JH, Alyea E, Koreth J, Cutler C, Armand P, Paik JM, Leaf DE, Ho VT, Abdi R. Impact of Thrombotic Microangiopathy on Renal Outcomes and Survival after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2018;24(11):2344-2353. PubMed

Leaf DE, Siew ED, Eisenga MF, Singh K, Mc Causland FR, Srivastava A, Ikizler TA, Ware LB, Ginde AA, Kellum JA, Palevsky PM, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. Clin J Am Soc Nephrol 2018;13(4):531-41. PubMed

Rabadi S, Udo I, Leaf DE, Waikar SS, Christov M. Acute blood loss stimulates fibroblast growth factor 23 production. Am J Physiol Renal Physiol 2018;314(1):F132-9. PubMed

2017

Kota SK, Pernicone E, Leaf DE, Stillman IE, Waikar SS, Kota SB. BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. J Am Soc Nephrol 2017;28(12):3473-8. PubMed

Eisenga MF, van Londen M, Leaf DE, Nolte IM, Navis G, Bakker SJL, de Borst MH, Gaillard CAJM. C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients. J Am Soc Nephrol 2017;28(12):3639-46. PubMed

Cui S, Vaingankar SM, Stenger A, Waikar SS, Leaf DE. Stability of Fibroblast Growth Factor 23 in Human Plasma. J Appl Lab Med 2017;729-734. PubMed

Leaf DE, Jacob KA, Srivastava A, Chen ME, Christov M, Jüppner H, Sabbisetti VS, Martin A, Wolf M, Waikar S. Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. J Am Soc Nephrol 2017;28(6):1877-85. PubMed

Leaf RK, O’Brien KL, Leaf DE, Drews RE. Autoimmune hemolytic anemia in a young man with acute hepatitis E infection. Am J Hematol 2017;92(5):E77-79. PubMed

Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med 2017;195(4):482-90. PubMed

Cortazar FB, Leaf DE, Owens CT, Laliberte K, Pendergraft WF, Niles JL. Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series. BMC Nephrol 2017;18(1):44. PubMed

Leaf DE and Waikar SS. End Points for Clinical Trials in Acute Kidney Injury. Am J Kidney Dis 2017;69(1):108-116. PubMed

2016

Leaf DE and Swinkels DW. Catalytic iron and acute kidney injury. Am J Physiol Renal Physiol 2016;311(5):F871-6. PubMed

Leaf DE, Body, SC, Muehlschlegel JD, McMahon GM, Lichtner P, Collard CD, Shernan SK, Fox AA, Waikar SS. Length Polymorphisms in Heme Oxygenase-1 and Risk of AKI following Cardiac Surgery. J Am Soc Nephrol 2016;27(11):3291-97. PubMed

Leaf DE, Cheng XS, Sanders JL, Mendu M, Schiff GD, Mount DB, Bazari H. An electronic alert to decrease Kayexalate ordering. Ren Fail 2016;38(10):1752-54. PubMed

Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. Clinical predictors of diagnostic testing utility in the initial evaluation of chronic kidney disease. Nephrology 2016;21(10):851-9. PubMed

Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE. Clinicopathological features of AKI associated with immune checkpoint inhibitors. Kidney Int 2016;90(3):638-47. PubMed

Leaf DE, Christov M, Jüppner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Cai X, Wolf M, Waikar SS. Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int 2016;89(4):939-48. PubMed

2015

Leaf DE, Srivastava A, Zeng X, McMahon GM, Croy HE, Mendu ML, Kachalia A, Waikar SS. Excessive diagnostic testing in acute kidney injury. BMC Nephrol 2016;17(1):9. PubMed

Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, Kluin J, Waikar SS. Intraoperative High-Dose Dexamethasone and Severe Acute Kidney Injury after Cardiac Surgery. J Am Soc Nephrol 2015;26(12):2947-51. PubMed

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Rawn J, Frendl G, Waikar SS. Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac Surgery. Kidney Int 2015;87(5):1046-54. PubMed

Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. The usefulness of diagnostic testing in the initial evaluation of chronic kidney disease. JAMA Intern Med 2015;175(5):853-6. PubMed

Leaf DE, Croy HE, Abrahams SJ, Raed A, Waikar SS. Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients. Crit Care 2015;19:80. PubMed

2014

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Waikar SS.  Plasma Catalytic Iron, AKI, and Death among Critically Ill Patients.  Clin J Am Soc Nephrol 2014;9(11):1849-56.  PubMed

Mendu ML, Schneider LI, Aizer AA, Singh K, Leaf DE, Lee TH, Waikar SS.  Implementation of a CKD Checklist for Primary Care Providers.  Clin J Am Soc Nephrol 2014;9(9):1526-35.  PubMed

Leaf DE, Waikar SS.  Rosuvastatin for sepsis-associated ARDS [letter].  N Engl J Med 2014;371(10): 968.  PubMed

Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS.  Randomized Controlled Trial of Calcitriol in Severe Sepsis.  Am J Respir Crit Care Med 2014;190(5): 533-41.  PubMed

Lu Y, Ossmann MM, Leaf DE, Factor PH.  Patient visibility and ICU mortality: a conceptual replication.  HERD 2014;7(2): 92-103.  PubMed

2013

Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int 2013;84(4): 776-85. PubMed

Leaf DE, Waikar SS, Wolf M, Cremers S, Bhan I, Stern L. Dysregulated Mineral Metabolism in Patients with Acute Kidney Injury and Risk of Adverse Outcomes. Clin Endocrinol 2013;79(4): 491-8. PubMed

Esenwa CC, Leaf DE. Colpocephaly in adults. BMJ Case Rep 2013. PubMed

Leaf DE, McMahon GM, Seifter JL. Chloride-liberal fluids and intracellular acidosis [letter]. Kidney Int 2013;83(5): 971. PubMed

Leaf DE, Pereira RC, Bazari H, Jüppner H. Oncogenic Osteomalacia due to FGF23-Expressing Colon Adenocarcinoma. J Clin Endocrinol Metab 2013;98(3):887-91. PubMed

Leaf DE and Wolf M. A Physiologic-Based Approach to the Evaluation of a Patient With Hyperphosphatemia. Am J Kidney Dis 2013;61(2):330-6. PubMed

2012 and Prior

Leaf DE, Wolf M, Waikar SS, Chase H, Christov M, Cremers S, Stern L. FGF-23 Levels in Patients with AKI and Risk of Adverse Outcomes. Clin J Am Soc Nephrol 2012;7(8):1217-23. PubMed

Leaf DE, Bukberg PR, Goldfarb DS. Laxative abuse, eating disorders, and kidney stones: a case report and review of the literature. Am J Kidney Dis 2012;60(2):295-8. PubMed

Leaf DE, Korets R, Taylor EN, Tang J, Asplin JR, Goldfarb DS, Gupta M, Curhan GC. Effect of Vitamin D Repletion on Urinary Calcium Excretion among Kidney Stone Formers. Clin J Am Soc Nephrol 2012;7(5):829-34. PubMed

Gershengorn HB, Wunsch H, Wahab R, Leaf DEBrodie D, Li G, Factor P. Impact of nonphysician staffing on outcomes in a medical ICU. Chest 2011;139(6):1347-53. PubMed

Leaf DE. Calcium kidney stones [letter]. N Engl J Med 2010;363(25): 2470. PubMed

Leaf DE, Appel GB, Radhakrishnan J. Glomerular disease: why is there a dearth of high quality clinical trials? Kidney Int 2010;78(4):337-42. PubMed

Leaf DEHomel P, Factor, PH. Relationship between ICU design and mortality. Chest 2010; 137(5):1022-7. PubMed

Leaf DE, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrology Dialysis Transplantation 2010;25(4):1335-37. PubMed

Leaf DE, Langer NB, Markowski M, Garratty G, Diuguid DL. A severe case of Cefoxitin-induced immune hemolytic anemia. Acta Haematol 2010;124(4):197-9. PubMed

Leaf DE, Leo J, Smith PR, Yee H, Stern A, Rosenthal PB, Cahill-Gallant EB, Pillinger MH. SOMOSAT: Utility of a web-based self-assessment tool in undergraduate medical education. Medical Teacher 2009;31(5):e211-9. PubMed

Leaf DE and Goldfarb DS. Interpretation and review of health-related quality of life data in CKD patients receiving treatment for anemia. Kidney Int 2009;75(1):15-24. PubMed

Leaf DE, Feig JE, Vasquez C, Riva PL, Yu C, Lader JM, Kontogeorgis A, Baron EL, Peters NS, Fisher EA, Gutstein DE, Morley GE. Connexin40 imparts Heterogeneity to Atrial Tissue. Circ Res 2008;103(9):1001-8. PubMed

Leaf DE and Goldfarb DS. Mechanisms of Action of Acetazolamide in the Prophylaxis and Treatment of Acute Mountain Sickness. J Appl Physiol 2007;102(4):1313-22. PubMed