Publications

View on PubMed

2020

Hayek SS,* Leaf DE,* Tahhan AS,* Raad M, Sharma S, Waikar SS, Sever S, Camacho A, Wang X, Dande RR, Ibrahim NE, Baron RM, Altintas MM, Wei C, Sheikh-Hamad D, Pan JS, Holliday M, Januzzi JL, Weisboard SD, Quyyumi AA, Reiser J. [*Equal Contribution] Soluble Urokinase Receptor and Acute Kidney Injury. N Engl J Med, 2020;382(5):416-426. Pubmed

Gupta S, Seethapathy H, Strohbehn IA, Frigault MJ, O’Donnell EK, Jacobson CA, Motwani SS, Parikh SM, Curhan GC, Reynolds KL, Leaf DE, Sise ME. Acute Kidney Injury and Electrolyte Abnormalities After Chimeric Antigen Receptor T-Cell (CAR-T) Therapy for Diffuse Large B-Cell Lymphoma. Am J Kid Dis 2020 [Epub ahead of print]. Pubmed

Cortazar FB, Kibbelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik AB, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020;31(2):435-446. Pubmed

2019

Averdunk L, Fitzner C, Levkovich T, Leaf DE, Sobotta M, Vieten J, Ochi A, Moeckel G, Marx G, Stoppe C. Secretory Leukocyte Protease Inhibitor (SLPI)-A Novel Predictive Biomarker of Acute Kidney Injury after Cardiac Surgery: A Prospective Observational Study. J Clin Med. 2019;8(11). Pubmed

Jacob KA, Leaf DE. Prevention of Cardiac Surgery-Associated Acute Kidney Injury: A Review of Current Strategies. Anesthesiol Clin 2019;37(4):729-749. Pubmed

Seethapthy H, Zhao S, Chute DF, Zubiri L, Oppong Y, Strohbehn I, Cortazar FB, Leaf DE, Mooradian MJ, Villani AC, Sullivan RJ, Reynolds K, Sise ME. The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors. Clin J Am Soc Nephrol 2019;14(12):1692-1700. Pubmed

Holliday AM, Gheihman G, Cooper C, Sullivan A, Ohyama H, Leaf DE,* Leaf RK.* [*Equal contribution]. High Prevalence of Imposterism Among Female Harvard Medical and Dental Students. J Gen Intern Med;2019 [Epub ahead of print]. Pubmed

Sharma S, Leaf DE. Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention. J Am Soc Nephrol;30(11):2060-2071. Pubmed

Blair RA, Leaf RK, Leaf DE. A Case of Severe Hypothyroidism due to Lenalidomide. Clin Case Rep 2019;7(9):1747-1749. Pubmed

Leaf DE, Waikar SS. IDEAL-ICU in Context. Clin J Am Soc Nephrol 2019;14(8):1264-67. Pubmed

Eisenga MF, de Jong MA, der Meer PV, Leaf DE, Huls G, Nolte IM, Gaillard CAJM, Bakker SJL, de Borst MH. Iron Deficiency, Elevated Erythropoietin, Fibroblast Growth Factor 23 and Mortality in the General Population of the Netherlands: a Cohort Study. PLoS Med 2019;16(6):e1002818. Pubmed

Leaf RK, Ferreri C, Rangachari D, Mier J, Witteles W, Ansstas G, Anagnostou T, Zubiri L, Piotrowska Z, Oo TH, Iberri D, Yarchoan M, Salama A, Johnson DB, Leavitt AD, Rahma O, Reynolds KL, Leaf DE. Clinical and Laboratory Features of Autoimmune Hemolytic Anemia Associated with Immune Checkpoint Inhibitors. Am J Hematol 2019;94(5):563-574. Pubmed

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Boerger EAS, Mc Causland FR, Eisenga MF, Singh K, Babitt JL, Kellum JA, Palevsky PM, Christov M, Waikar SS. Iron, Hepcidin, and Death in Human Acute Kidney Injury. J Am Soc Nephrol 2019;30(3):493-504. Pubmed

Srivastava A, Palsson R, Leaf DE, Higuera A, Chen ME, Palacios P, Baron RM, Sabbisetti V, Hoofnagle AN, Vaingankar SM, Palevsky PM, Waikar SS. Uric Acid and Acute Kidney Injury in the Critically Ill. Kidney Med 2019. Link

Christov M, Neyra JA, Gupta S, Leaf DE. Fibroblast Growth Factor 23 and Klotho in AKI. Semin Nephrol 2019;39(1):57-75. Pubmed

Leaf DE, Christov M. Dysregulated Mineral Metabolism in AKI. Semin Nephrol 2019;39(1):41-56. Pubmed

Leaf DE. Introduction: Cross-Talk Between the Kidneys and Remote Organ Systems in AKI. Semin Nephrol 2019;39(1):1-2. Pubmed

2018

Poyan Mehr A, Tran MT, Ralto KM, Leaf DE, Washco V, Messmer J, Lerner A, Kher AV, Kim SH, Khoury CC, Herzig SJ, Trovato ME, Simon-Tillaux N, Lynch MR, Thadhani RI, Clish CB, Khabbaz KR, Rhee EP, Waikar SS, Berg AH, Parikh SM. De novo NAD+ biosynthetic impairment in acute kidney injury in humans. Nat Med 2018;24(9):1351-59. Pubmed

Neyra JA, Leaf DE. Risk Prediction Models for Acute Kidney Injury in Critically Ill Patients: Opus in Progressu. Nephron 2018;140(2):99-104. Pubmed

Postalcioglu M, Kim HT, Obut F, Yilmam OA, Yang J, Byun BC, Kupiec-Weglinski S, Soiffer R, Ritz J, Antin JH, Alyea E, Koreth J, Cutler C, Armand P, Paik JM, Leaf DE, Ho VT, Abdi R. Impact of Thrombotic Microangiopathy on Renal Outcomes and Survival after Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 2018;24(11):2344-2353. PubMed

Leaf DE, Siew ED, Eisenga MF, Singh K, Mc Causland FR, Srivastava A, Ikizler TA, Ware LB, Ginde AA, Kellum JA, Palevsky PM, Wolf M, Waikar SS. Fibroblast Growth Factor 23 Associates with Death in Critically Ill Patients. Clin J Am Soc Nephrol 2018;13(4):531-41. PubMed

Rabadi S, Udo I, Leaf DE, Waikar SS, Christov M. Acute blood loss stimulates fibroblast growth factor 23 production. Am J Physiol Renal Physiol 2018;314(1):F132-9. PubMed

2017

Kota SK, Pernicone E, Leaf DE, Stillman IE, Waikar SS, Kota SB. BPI Fold-Containing Family A Member 2/Parotid Secretory Protein Is an Early Biomarker of AKI. J Am Soc Nephrol 2017;28(12):3473-8. PubMed

Eisenga MF, van Londen M, Leaf DE, Nolte IM, Navis G, Bakker SJL, de Borst MH, Gaillard CAJM. C-Terminal Fibroblast Growth Factor 23, Iron Deficiency, and Mortality in Renal Transplant Recipients. J Am Soc Nephrol 2017;28(12):3639-46. PubMed

Cui S, Vaingankar SM, Stenger A, Waikar SS, Leaf DE. Stability of Fibroblast Growth Factor 23 in Human Plasma. J Appl Lab Med 2017;729-734. Link

Leaf DE, Jacob KA, Srivastava A, Chen ME, Christov M, Jüppner H, Sabbisetti VS, Martin A, Wolf M, Waikar S. Fibroblast Growth Factor 23 Levels Associate with AKI and Death in Critical Illness. J Am Soc Nephrol 2017;28(6):1877-85. PubMed

Leaf RK, O’Brien KL, Leaf DE, Drews RE. Autoimmune hemolytic anemia in a young man with acute hepatitis E infection. Am J Hematol 2017;92(5):E77-79. PubMed

Zhao B, Lu Q, Cheng Y, Belcher JM, Siew ED, Leaf DE, Body SC, Fox AA, Waikar SS, Collard CD, Thiessen-Philbrook H, Ikizler TA, Ware LB, Edelstein CL, Garg AX, Choi M, Schaub JA, Zhao H, Lifton RP, Parikh CR. A Genome-Wide Association Study to Identify Single Nucleotide Polymorphisms for Acute Kidney Injury. Am J Respir Crit Care Med 2017;195(4):482-90. PubMed

Cortazar FB, Leaf DE, Owens CT, Laliberte K, Pendergraft WF, Niles JL. Combination therapy with rituximab, low-dose cyclophosphamide, and prednisone for idiopathic membranous nephropathy: a case series. BMC Nephrol 2017;18(1):44. PubMed

Leaf DE and Waikar SS. End Points for Clinical Trials in Acute Kidney Injury. Am J Kidney Dis 2017;69(1):108-116. PubMed

2016

Leaf DE and Swinkels DW. Catalytic iron and acute kidney injury. Am J Physiol Renal Physiol 2016;311(5):F871-6. PubMed

Leaf DE, Body, SC, Muehlschlegel JD, McMahon GM, Lichtner P, Collard CD, Shernan SK, Fox AA, Waikar SS. Length Polymorphisms in Heme Oxygenase-1 and Risk of AKI following Cardiac Surgery. J Am Soc Nephrol 2016;27(11):3291-97. PubMed

Leaf DE, Cheng XS, Sanders JL, Mendu M, Schiff GD, Mount DB, Bazari H. An electronic alert to decrease Kayexalate ordering. Ren Fail 2016;38(10):1752-54. PubMed

Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. Clinical predictors of diagnostic testing utility in the initial evaluation of chronic kidney disease. Nephrology 2016;21(10):851-9. PubMed

Cortazar FB, Marrone KA, Troxell ML, Ralto KM, Hoenig MP, Brahmer JR, Le DT, Lipson EJ, Glezerman IG, Wolchok J, Cornell LD, Feldman P, Stokes MB, Zapata SA, Hodi FS, Ott PA, Yamashita M, Leaf DE. Clinicopathological features of AKI associated with immune checkpoint inhibitors. Kidney Int 2016;90(3):638-47. PubMed

Leaf DE, Christov M, Jüppner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Cai X, Wolf M, Waikar SS. Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int 2016;89(4):939-48. PubMed

2015

Leaf DE, Srivastava A, Zeng X, McMahon GM, Croy HE, Mendu ML, Kachalia A, Waikar SS. Excessive diagnostic testing in acute kidney injury. BMC Nephrol 2016;17(1):9. PubMed

Jacob KA, Leaf DE, Dieleman JM, van Dijk D, Nierich AP, Rosseel PM, van der Maaten JM, Hofland J, Diephuis JC, de Lange F, Boer C, Kluin J, Waikar SS. Intraoperative High-Dose Dexamethasone and Severe Acute Kidney Injury after Cardiac Surgery. J Am Soc Nephrol 2015;26(12):2947-51. PubMed

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Rawn J, Frendl G, Waikar SS. Increased plasma catalytic iron in patients may mediate acute kidney injury and death following cardiac Surgery. Kidney Int 2015;87(5):1046-54. PubMed

Mendu ML, Lundquist A, Aizer AA, Leaf DE, Robinson E, Steele DJ, Waikar SS. The usefulness of diagnostic testing in the initial evaluation of chronic kidney disease. JAMA Intern Med 2015;175(5):853-6. PubMed

Leaf DE, Croy HE, Abrahams SJ, Raed A, Waikar SS. Cathelicidin antimicrobial protein, vitamin D, and risk of death in critically ill patients. Crit Care 2015;19:80. PubMed

2014

Leaf DE, Rajapurkar M, Lele SS, Mukhopadhyay B, Waikar SS.  Plasma Catalytic Iron, AKI, and Death among Critically Ill Patients.  Clin J Am Soc Nephrol 2014;9(11):1849-56.  PubMed

Mendu ML, Schneider LI, Aizer AA, Singh K, Leaf DE, Lee TH, Waikar SS.  Implementation of a CKD Checklist for Primary Care Providers.  Clin J Am Soc Nephrol 2014;9(9):1526-35.  PubMed

Leaf DE, Waikar SS.  Rosuvastatin for sepsis-associated ARDS [letter].  N Engl J Med 2014;371(10): 968.  PubMed

Leaf DE, Raed A, Donnino MW, Ginde AA, Waikar SS.  Randomized Controlled Trial of Calcitriol in Severe Sepsis.  Am J Respir Crit Care Med 2014;190(5): 533-41.  PubMed

Lu Y, Ossmann MM, Leaf DE, Factor PH.  Patient visibility and ICU mortality: a conceptual replication.  HERD 2014;7(2): 92-103.  PubMed

2013

Christov M, Waikar SS, Pereira RC, Havasi A, Leaf DE, Goltzman D, Pajevic PD, Wolf M, Jüppner H. Plasma FGF23 levels increase rapidly after acute kidney injury. Kidney Int 2013;84(4): 776-85. PubMed

Leaf DE, Waikar SS, Wolf M, Cremers S, Bhan I, Stern L. Dysregulated Mineral Metabolism in Patients with Acute Kidney Injury and Risk of Adverse Outcomes. Clin Endocrinol 2013;79(4): 491-8. PubMed

Esenwa CC, Leaf DE. Colpocephaly in adults. BMJ Case Rep 2013. PubMed

Leaf DE, McMahon GM, Seifter JL. Chloride-liberal fluids and intracellular acidosis [letter]. Kidney Int 2013;83(5): 971. PubMed

Leaf DE, Pereira RC, Bazari H, Jüppner H. Oncogenic Osteomalacia due to FGF23-Expressing Colon Adenocarcinoma. J Clin Endocrinol Metab 2013;98(3):887-91. PubMed

Leaf DE and Wolf M. A Physiologic-Based Approach to the Evaluation of a Patient With Hyperphosphatemia. Am J Kidney Dis 2013;61(2):330-6. PubMed

2012 and Prior

Leaf DE, Wolf M, Waikar SS, Chase H, Christov M, Cremers S, Stern L. FGF-23 Levels in Patients with AKI and Risk of Adverse Outcomes. Clin J Am Soc Nephrol 2012;7(8):1217-23. PubMed

Leaf DE, Bukberg PR, Goldfarb DS. Laxative abuse, eating disorders, and kidney stones: a case report and review of the literature. Am J Kidney Dis 2012;60(2):295-8. PubMed

Leaf DE, Korets R, Taylor EN, Tang J, Asplin JR, Goldfarb DS, Gupta M, Curhan GC. Effect of Vitamin D Repletion on Urinary Calcium Excretion among Kidney Stone Formers. Clin J Am Soc Nephrol 2012;7(5):829-34. PubMed

Gershengorn HB, Wunsch H, Wahab R, Leaf DEBrodie D, Li G, Factor P. Impact of nonphysician staffing on outcomes in a medical ICU. Chest 2011;139(6):1347-53. PubMed

Leaf DE. Calcium kidney stones [letter]. N Engl J Med 2010;363(25): 2470. PubMed

Leaf DE, Appel GB, Radhakrishnan J. Glomerular disease: why is there a dearth of high quality clinical trials? Kidney Int 2010;78(4):337-42. PubMed

Leaf DEHomel P, Factor, PH. Relationship between ICU design and mortality. Chest 2010; 137(5):1022-7. PubMed

Leaf DE, Wolf M, Stern L. Elevated FGF-23 in a patient with rhabdomyolysis-induced acute kidney injury. Nephrology Dialysis Transplantation 2010;25(4):1335-37. PubMed

Leaf DE, Langer NB, Markowski M, Garratty G, Diuguid DL. A severe case of Cefoxitin-induced immune hemolytic anemia. Acta Haematol 2010;124(4):197-9. PubMed

Leaf DE, Leo J, Smith PR, Yee H, Stern A, Rosenthal PB, Cahill-Gallant EB, Pillinger MH. SOMOSAT: Utility of a web-based self-assessment tool in undergraduate medical education. Medical Teacher 2009;31(5):e211-9. PubMed

Leaf DE and Goldfarb DS. Interpretation and review of health-related quality of life data in CKD patients receiving treatment for anemia. Kidney Int 2009;75(1):15-24. PubMed

Leaf DE, Feig JE, Vasquez C, Riva PL, Yu C, Lader JM, Kontogeorgis A, Baron EL, Peters NS, Fisher EA, Gutstein DE, Morley GE. Connexin40 imparts Heterogeneity to Atrial Tissue. Circ Res 2008;103(9):1001-8. PubMed

Leaf DE and Goldfarb DS. Mechanisms of Action of Acetazolamide in the Prophylaxis and Treatment of Acute Mountain Sickness. J Appl Physiol 2007;102(4):1313-22. PubMed